Journal article
Abnormal social reward responses in anorexia nervosa: An fmri study
E Via, C Soriano-Mas, I Sánchez, L Forcano, BJ Harrison, CG Davey, J Pujol, I Martínez-Zalacaín, JM Menchón, F Fernández-Aranda, N Cardoner
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2015
Abstract
Patients with anorexia nervosa (AN) display impaired social interactions, implicated in the development and prognosis of the disorder. Importantly, social behavior is modulated by reward-based processes, and dysfunctional at-brain-level reward responses have been involved in AN neurobiological models. However, no prior evidence exists of whether these neural alterations would be equally present in social contexts. In this study, we conducted a cross-sectional social-judgment functional magnetic resonance imaging (fMRI) study of 20 restrictive-subtype AN patients and 20 matched healthy controls. Brain activity during acceptance and rejection was investigated and correlated with severity measu..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported in part by the Carlos III Health Institute (ISCIII, PI08/1549, PI11/210 and PI14/290) and by Fondos Europeos de Desarrollo Regional (FEDER). CIBERobn and CIBERSAM are both initiatives of ISCIII.). Dr. Soriano-Mas is funded by a 'Miguel Servet' contract from the Carlos III Health Institute (I.D. CP10/00604). A/Prof. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Fellowship (I.D. 628509). Dr. Davey is supported by a NHMRC Clinical Career Development Fellowship (I.D. 1061757). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.